ACE INHIBITORS AND CLONIDINE

ACE inhibitors may potentiate the antihypertensive effects of clonidine, and this can be clinically useful. However, limited evidence suggests that the effects of captopril may be delayed when patients are switched from clonidine. Note that sudden withdrawal of clonidine may cause rebound hypertension.
The general importance of this interaction is unknown, but be aware that it may occur.