ACICLOVIR AND MYCOPHENOLATE
No clinically significant pharmacokinetic interaction appears to occur between aciclovir and mycophenolate. However, the manufacturers say that in renal impair- ment there may be competition for tubular secretion and increased concentrations of both drugs may occur. This is also possible with valaciclovir. A case report describes neutropenia in a patient taking valaciclovir with mycophenolate.
No action is needed, but increased monitoring may be prudent in patients with reduced renal function. Neutropenia is a rare adverse effect of valaciclovir alone. Nevertheless, bear the possibility of an interaction in mind should neutropenia occur if mycophenolate is also given.
No action is needed, but increased monitoring may be prudent in patients with reduced renal function. Neutropenia is a rare adverse effect of valaciclovir alone. Nevertheless, bear the possibility of an interaction in mind should neutropenia occur if mycophenolate is also given.