ALLOPURINOL AND ANTIDIABETICS

Although allopurinol affects the half-life of chlorpropamide and tolbutamide, and a case of diabetic coma has been seen in a patient taking gliclazide and allopurinol, there appears to be little information to suggest that a clinically significant interaction usually occurs with sulphonylureas.
Bear these potential interactions in mind in case of an unexpected response to treatment.