ALLOPURINOL AND CARBAMAZEPINE
There is some evidence to suggest that high-dose allopurinol (15 mg/kg or 600 mg daily) can gradually raise serum carbamazepine levels by about one-third. It appears that allopurinol 300 mg daily has no effect on carbamazepine levels.
This interaction may take weeks or months to develop. Warn patients taking high- dose allopurinol to monitor for indicators of carbamazepine toxicity, which include nausea, vomiting, ataxia and drowsiness. Monitor carbamazepine levels as necessary.
This interaction may take weeks or months to develop. Warn patients taking high- dose allopurinol to monitor for indicators of carbamazepine toxicity, which include nausea, vomiting, ataxia and drowsiness. Monitor carbamazepine levels as necessary.