.

ANTIHISTAMINES AND RIFAMPICIN (RIFAMPIN)

Medical Diagnosis and Drugs, Medications
Rifampicin increases the oral clearance of fexofenadine, by more than 5-fold in some cases, but the clinical significance of this is unclear.
Until more is known it would seem prudent to monitor the efficacy of fexofenadine if it is given with rifampicin.
(6)