APREPITANT AND CONTRACEPTIVES
Aprepitant reduces the levels of ethinylestradiol and norethisterone (given as a combined hormonal contraceptive). Greater effects were seen in another study when dexamethasone was also given with aprepitant. Fosaprepitant, a prodrug of aprepitant, would be expected to interact similarly.
Although the effects of these reduced contraceptive steroid levels on ovulation were not assessed, it is likely that they could result in reduced efficacy. The manufacturer recommends that alternative or additional contraceptive methods should be used during aprepitant therapy and for 2 months (UK advice) or one month (US advice) after the last dose of aprepitant. For general advice on the use of enzyme inducers and contraceptives, see contraceptives.
Although the effects of these reduced contraceptive steroid levels on ovulation were not assessed, it is likely that they could result in reduced efficacy. The manufacturer recommends that alternative or additional contraceptive methods should be used during aprepitant therapy and for 2 months (UK advice) or one month (US advice) after the last dose of aprepitant. For general advice on the use of enzyme inducers and contraceptives, see contraceptives.