APREPITANT AND ERGOT DERIVATIVES
Aprepitant can increase the levels of the ergot derivatives in the short-term, then reduce them within 2 weeks. Ergotism could occur. Fosaprepitant, a prodrug of aprepitant, would be expected to interact similarly.
The effect may persist for 2 weeks after aprepitant is stopped. Avoid the combination where possible. Concurrent use needs close monitoring.
The effect may persist for 2 weeks after aprepitant is stopped. Avoid the combination where possible. Concurrent use needs close monitoring.