APREPITANT AND HRT

Aprepitant reduces the levels of ethinylestradiol and norethisterone (given as a combined hormonal contraceptive). Greater effects were seen in another study when dexamethasone was also given with aprepitant. The hormones in HRT are similar to those used in hormonal contraceptives, and so may be affected by enzyme-inducing drugs in the same way. Note that fosaprepitant, a prodrug of aprepitant, would also be expected to reduce HRT levels.
Consider the possibility of reduced HRT efficacy.