ASPIRIN AND DIURETICS - SPIRONOLACTONE

Although studies in healthy subjects have found that the spironolactone-induced loss of sodium in the urine is reduced, a study in hypertensive patients showed that the blood pressure lowering effects of spironolactone were not affected by aspirin.
Concurrent use need not be avoided, but if the diuretic response to spironolactone is less than expected, consider this interaction as a cause.