ATOMOXETINE AND TERBINAFINE
Paroxetine increases the AUC and levels of atomoxetine by 6.5-fold and 3.5-fold, respectively by inhibiting its metabolism by CYP2D6. Terbinafine, also a CYP2D6 inhibitor, is expected to interact similarly.
The atomoxetine dose should be titrated slowly with the dose increased only if symptoms fail to improve and if the initial dose is well tolerated. The UK manufacturers say that the initial dose should be maintained for a minimum of 7 days before considering an increase.
The atomoxetine dose should be titrated slowly with the dose increased only if symptoms fail to improve and if the initial dose is well tolerated. The UK manufacturers say that the initial dose should be maintained for a minimum of 7 days before considering an increase.