AZOLES AND BENZODIAZEPINES - MIDAZOLAM AND TRIAZOLAM
Fluconazole, itraconazole, and ketoconazole very markedly increase the bioavailability of oral midazolam and triazolam (AUCs increased by 3.5-fold to about 15-fold), thereby increasing and prolonging their sedative and amnesic effects.
Expect increased and prolonged sedation. It may be prudent to reduce the dose of midazolam or triazolam by at least 50% with fluconazole and by 75% with itraconazole or ketoconazole. Other azoles are likely to interact similarly.
Expect increased and prolonged sedation. It may be prudent to reduce the dose of midazolam or triazolam by at least 50% with fluconazole and by 75% with itraconazole or ketoconazole. Other azoles are likely to interact similarly.