AZOLES AND BUSULFAN
Itraconazole reduces the clearance of busulfan by a modest 20%. There is some limited evidence that ketoconazole may increase the risk of hepatic veno-occlusive disease in those given high-dose busulfan.
Although the rise in levels is only moderate, it would be prudent to monitor for busulfan toxicity. Fluconazole appears not to interact, and so may be a useful alternative.
Although the rise in levels is only moderate, it would be prudent to monitor for busulfan toxicity. Fluconazole appears not to interact, and so may be a useful alternative.