AZOLES AND CARBAMAZEPINE - ITRACONAZOLE, POSACONAZOLE, OR VORICONAZOLE
Carbamazepine, either alone or when given with phenobarbital or phenytoin, has been shown to decrease itraconazole levels resulting in treatment failure. Carbama- zepine is predicted to decrease posaconazole and voriconazole levels.
Concurrent use should be avoided unless the benefits are expected to outweigh the risks, although note that the use of voriconazole is specifically contraindicated. If concurrent use is necessary it seems likely that the antifungal dose will need to be increased. It would seem prudent to use other alternatives wherever possible or monitor efficacy very closely.
Concurrent use should be avoided unless the benefits are expected to outweigh the risks, although note that the use of voriconazole is specifically contraindicated. If concurrent use is necessary it seems likely that the antifungal dose will need to be increased. It would seem prudent to use other alternatives wherever possible or monitor efficacy very closely.