AZOLES AND CICLOSPORIN (CYCLOSPORINE) - VORICONAZOLE
Voriconazole increases the AUC of ciclosporin in stable renal transplant patients by between about 1.7- and 2.5-fold.
The dose of ciclosporin should be halved when initiating voriconazole, and ciclosporin levels should be carefully monitored during treatment. The ciclosporin dose should be increased again when voriconazole is withdrawn.
The dose of ciclosporin should be halved when initiating voriconazole, and ciclosporin levels should be carefully monitored during treatment. The ciclosporin dose should be increased again when voriconazole is withdrawn.