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AZOLES AND MIRTAZAPINE

Medical Diagnosis and Drugs, Medications
Ketoconazole is reported to increase the peak plasma levels and AUC of mirtazapine by about 30% and 45%, respectively.
The manufacturers of mirtazapine advise caution on concurrent use with itraconazole or ketoconazole. Monitor for adverse effects (e.g. oedema, sedation).
(1)