AZOLES AND NRTIS - ZIDOVUDINE
In one study fluconazole increased the AUC of zidovudine by 74% but other studies have found that fluconazole causes only slight changes in zidovudine pharmacoki- netics. Increased zidovudine levels, thought to be caused by itraconazole, have been seen in two cases.
Be aware that concurrent use may rarely result in zidovudine toxicity.
Be aware that concurrent use may rarely result in zidovudine toxicity.