AZOLES AND NSAIDS
Fluconazole increases the AUC of celecoxib by 130%. The AUC of the active metabolite of parecoxib (valdecoxib) is increased by 62% by fluconazole.
The manufacturers recommend that half the dose of celecoxib should be used in patients taking fluconazole. A dose reduction of parecoxib is recommended in patients taking fluconazole.
The manufacturers recommend that half the dose of celecoxib should be used in patients taking fluconazole. A dose reduction of parecoxib is recommended in patients taking fluconazole.