AZOLES AND OPIOIDS - METHADONE
Fluconazole may increase the levels and AUC of methadone by about 30%; a single case reports opioid toxicity. Ketoconazole and voriconazole appear to interact with methadone to a greater extent (methadone levels raised by 50% or more).
Patients given these azoles with methadone should be monitored for signs of opioid toxicity and a methadone dose alteration should be considered. However, note that the interaction with fluconazole is considered unlikely to be of general clinical significance.
Patients given these azoles with methadone should be monitored for signs of opioid toxicity and a methadone dose alteration should be considered. However, note that the interaction with fluconazole is considered unlikely to be of general clinical significance.