AZOLES AND PHENYTOIN - FLUCONAZOLE, OR MICONAZOLE
Phenytoin toxicity has been seen in some patients given fluconazole or miconazole. Phenytoin may reduce fluconazole levels. Fosphenytoin, a prodrug of phenytoin, may interact similarly.
Toxicity can develop within 2 to 7 days. Monitor serum phenytoin levels closely and reduce the dosage appropriately. Also be alert for any evidence of reduced antifungal effects and consider increasing the dose. Note that, at high doses, miconazole oral gel has the potential to interact.
Toxicity can develop within 2 to 7 days. Monitor serum phenytoin levels closely and reduce the dosage appropriately. Also be alert for any evidence of reduced antifungal effects and consider increasing the dose. Note that, at high doses, miconazole oral gel has the potential to interact.