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AZOLES AND PRAZIQUANTEL

Medical Diagnosis and Drugs, Medications
Ketoconazole almost doubles the AUC of praziquantel, which appears to increase the incidence of mild adverse effects (headache and gastrointestinal adverse effects, including nausea and vomiting).
Information is limited, but all azoles have the potential to interact, to a greater or lesser extent. It may be prudent to be alert for an increase in the adverse effects of praziquantel, although an increase in efficacy is also possible.
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