AZOLES AND REBOXETINE
Ketoconazole decreases the clearance of reboxetine, without apparently altering its adverse effect profile. Other azoles are predicted to interact similarly.
It has been suggested that caution should be used, and a reduction in reboxetine dosage considered, if it is given with ketoconazole. The manufacturers recommend that azoles should not be given with reboxetine as it has a narrow therapeutic index, but this seems overly cautious.
It has been suggested that caution should be used, and a reduction in reboxetine dosage considered, if it is given with ketoconazole. The manufacturers recommend that azoles should not be given with reboxetine as it has a narrow therapeutic index, but this seems overly cautious.