AZOLES AND RIFABUTIN - ITRACONAZOLE OR KETOCONAZOLE
Rifabutin reduces the plasma levels of itraconazole. Uveitis was attributed to the concurrent use of rifabutin and itraconazole in one report. Ketoconazole is predicted to interact similarly.
Information is sparse, but based on what is known monitor for reduced antifungal activity, raising the azole dosage as necessary, and watch for increased rifabutin levels and toxicity (in particular uveitis).
Information is sparse, but based on what is known monitor for reduced antifungal activity, raising the azole dosage as necessary, and watch for increased rifabutin levels and toxicity (in particular uveitis).