AZOLES AND RIFAMPICIN (RIFAMPIN) - KETOCONAZOLE
Ketoconazole levels can be reduced by 50 to 80% by rifampicin. Rifampicin levels can be halved by ketoconazole, but are possibly unaffected if the drugs are given 12 hours apart.
Wherever possible avoid concurrent use. If the combination must be used, monitor efficacy closely, being aware that a reduced effect is highly likely. Consider increasing the doses of both drugs.
Wherever possible avoid concurrent use. If the combination must be used, monitor efficacy closely, being aware that a reduced effect is highly likely. Consider increasing the doses of both drugs.