AZOLES AND SIROLIMUS - FLUCONAZOLE
In one case fluconazole caused a significant increase in sirolimus levels despite dose reductions from 4 mg to 2 mg.
Close monitoring of sirolimus levels is recommended.
Ketoconazole or Itraconazole
Ketoconazole increases the maximum serum levels of sirolimus by 4.3-fold. Itraconazole increases the levels of sirolimus and dosage reductions of up to 90% have been required.
Concurrent use is not recommended.
Close monitoring of sirolimus levels is recommended.
Ketoconazole or Itraconazole
Ketoconazole increases the maximum serum levels of sirolimus by 4.3-fold. Itraconazole increases the levels of sirolimus and dosage reductions of up to 90% have been required.
Concurrent use is not recommended.