AZOLES AND SOLIFENACIN
Ketoconazole increases solifenacin levels 2- to 3-fold by inhibiting CYP3A4. The manufacturers predict that other CYP3A4 inhibitors (e.g. itraconazole) will have the same effect.
It is recommended that only 5 mg of solifenacin should be used in patients taking itraconazole or ketoconazole. The concurrent use of solifenacin and these azoles is contraindicated in patients with severe renal impairment or moderate hepatic impairment.
It is recommended that only 5 mg of solifenacin should be used in patients taking itraconazole or ketoconazole. The concurrent use of solifenacin and these azoles is contraindicated in patients with severe renal impairment or moderate hepatic impairment.