AZOLES AND STATINS - FLUVASTATIN
Fluconazole increases the AUC and maximum plasma levels of fluvastatin by 84% and 44%, respectively.
The clinical relevance of the modest changes in fluvastatin levels with fluconazole is unclear. However, because of the potentially serious reactions that can result, any patient given fluvastatin, with fluconazole (or miconazole, including the oral gel) should be told to report any unexplained muscle pain, tenderness or weakness.
The clinical relevance of the modest changes in fluvastatin levels with fluconazole is unclear. However, because of the potentially serious reactions that can result, any patient given fluvastatin, with fluconazole (or miconazole, including the oral gel) should be told to report any unexplained muscle pain, tenderness or weakness.