AZOLES AND TOLTERODINE
The AUC of tolterodine is raised by more than 2-fold by ketoconazole. Itraconazole is predicted to interact similarly.
The UK manufacturers advise avoiding concurrent use. The US manufacturers suggest reducing the tolterodine dose to 1 mg twice daily, which seems practical. If both drugs are given monitor carefully for tolterodine adverse effects, and further reduce the dose if necessary.
The UK manufacturers advise avoiding concurrent use. The US manufacturers suggest reducing the tolterodine dose to 1 mg twice daily, which seems practical. If both drugs are given monitor carefully for tolterodine adverse effects, and further reduce the dose if necessary.