BENZODIAZEPINES AND CARBAMAZEPINE - CLOBAZAM

Carbamazepine reduces the levels of clobazam and increases the levels of its principal metabolite. A case report describes a small rise in carbamazepine levels resulting in toxicity in a patient also taking clobazam, whereas a small study suggested that clobazam increased the metabolism of carbamazepine.
The clinical significance of these findings is unknown. The changes in clobazam levels are not expected to be clinically significant.