BENZODIAZEPINES AND DISULFIRAM
An isolated and unconfirmed report describes temazepam toxicity, possibly due to disulfiram. The serum levels of chlordiazepoxide and diazepam are increased by the use of disulfiram and some patients may possibly experience increased drowsiness.
If sedation occurs reduce the dosage of the benzodiazepine if necessary. Other benzodiazepines that are metabolised similarly may possibly interact in the same way (e.g. bromazepam, clobazam, clonazepam, clorazepate, flurazepam, ketazo- lam, medazepam, nitrazepam, prazepam) but this needs confirmation. Alprazo- lam, lorazepam and oxazepam appear to be non-interacting alternatives.
If sedation occurs reduce the dosage of the benzodiazepine if necessary. Other benzodiazepines that are metabolised similarly may possibly interact in the same way (e.g. bromazepam, clobazam, clonazepam, clorazepate, flurazepam, ketazo- lam, medazepam, nitrazepam, prazepam) but this needs confirmation. Alprazo- lam, lorazepam and oxazepam appear to be non-interacting alternatives.