BENZODIAZEPINES AND ISONIAZID
Isoniazid reduces the clearance of both diazepam and triazolam. Some increase in their effects would be expected.
The degree of sedation will depend on the individual patient. However, warn all patients of the potential effects, and counsel against driving or undertaking other skilled tasks. Reduce the benzodiazepine dose as necessary. Clotiazepam and oxazepam appear to be non-interacting alternatives.
The degree of sedation will depend on the individual patient. However, warn all patients of the potential effects, and counsel against driving or undertaking other skilled tasks. Reduce the benzodiazepine dose as necessary. Clotiazepam and oxazepam appear to be non-interacting alternatives.