BENZODIAZEPINES AND MACROLIDES - OTHER BENZODIAZEPINES
Roxithromycin has a weak effect on the metabolism of midazolam and triazolam, and erythromycin has a weak effect on the metabolism of diazepam, flunitrazepam, nitrazepam, temazepam and zaleplon. Erythromycin possibly increases the effects of alprazolam.
The general significance of these modest interactions are unclear, but it may be prudent to monitor the outcome of concurrent use, reducing the dose of the benzodiazepine if necessary.
The general significance of these modest interactions are unclear, but it may be prudent to monitor the outcome of concurrent use, reducing the dose of the benzodiazepine if necessary.