BENZODIAZEPINES AND MODAFINIL
Modafinil reduced the maximum plasma concentration of triazolam by 42% and reduced its elimination half-life by about one hour. Alprazolam and midazolam may be similarly affected. In contrast, diazepam levels may be increased by modafinil.
Dosage adjustments may be necessary on concurrent use. Monitor to ensure that the benzodiazepine effects are adequate, and, in the case of diazepam, not excessive.
Dosage adjustments may be necessary on concurrent use. Monitor to ensure that the benzodiazepine effects are adequate, and, in the case of diazepam, not excessive.