BENZODIAZEPINES AND PHENOBARBITAL
Clonazepam appears to markedly raise the levels of primidone in children, and
toxicity has been seen. The concurrent use of primidone and clorazepate was thought to have caused irritability, aggression and depression in a small number of patients. Note that primidone is metabolized to phenobarbital.
The clinical importance of this interaction is unknown, but bear it in mind in case of an unexpected response to treatment. Indicators of phenobarbital and primidone toxicity include drowsiness, ataxia, and dysarthria.
toxicity has been seen. The concurrent use of primidone and clorazepate was thought to have caused irritability, aggression and depression in a small number of patients. Note that primidone is metabolized to phenobarbital.
The clinical importance of this interaction is unknown, but bear it in mind in case of an unexpected response to treatment. Indicators of phenobarbital and primidone toxicity include drowsiness, ataxia, and dysarthria.