BENZODIAZEPINES AND PROTEASE INHIBITORS - OTHER BENZODIAZEPINES
Ritonavir is predicted to raise the levels of a number of benzodiazepines and related drugs, which would be expected to result in increased and prolonged sedation.
Clorazepate, diazepam, estazolam, and flurazepam are contraindicated by the UK manufacturer of ritonavir, but cautioned by the US manufacturers of ritonavir, amprenavir, and fosamprenavir, and both the UK and US manufacturers of saquinavir: some advise that a reduction in the dose of these benzodiazepines may be necessary. Alprazolam is contraindicated by the UK and US manufacturers of indinavir. The manufacturer of ritonavir notes that zolpidem may be given concurrently with careful monitoring for excessive sedative effects and consider- ation of reducing the dose of zolpidem.
Clorazepate, diazepam, estazolam, and flurazepam are contraindicated by the UK manufacturer of ritonavir, but cautioned by the US manufacturers of ritonavir, amprenavir, and fosamprenavir, and both the UK and US manufacturers of saquinavir: some advise that a reduction in the dose of these benzodiazepines may be necessary. Alprazolam is contraindicated by the UK and US manufacturers of indinavir. The manufacturer of ritonavir notes that zolpidem may be given concurrently with careful monitoring for excessive sedative effects and consider- ation of reducing the dose of zolpidem.