BENZODIAZEPINES AND PROTON PUMP INHIBITORS

Gait disturbances (attributed to benzodiazepine toxicity) occurred in 2 patients given triazolam, and lorazepam or flurazepam, with omeprazole. Another patient taking diazepam and omeprazole became wobbly and sedated. Lansoprazole, pantoprazole, or rabeprazole appear not to interact with diazepam to a clinically relevant extent. Diazepam serum levels are increased by esomeprazole but the clinical relevance of this is unknown.
Information is sparse. Bear this interaction in mind if excessive benzodiazepine effects occur.