BENZODIAZEPINES AND SSRIS
On the whole, no clinically significant interaction appears to occur between the SSRIs and the benzodiazepines or related drugs, such as cloral hydrate or zaleplon. However, there is some evidence to suggest that the metabolism of some benzodiazepines (such as alprazolam, bromazepam and diazepam, and also possibly midazolam, nitrazepam and triazolam) may be reduced by some SSRIs (such as fluoxetine and fluvoxamine). There is some evidence to support the suggestion that sedation is likely to be increased by the concurrent use of SSRIs and benzodiazepines. Rare cases of hallucinations have been seen with zolpidem and some SSRIs.
No particular action is necessary but remember that the degree of sedation will depend on the individual patient and drug combination. Warn all patients of the potential effects, and counsel caution with driving or undertaking other skilled tasks.
No particular action is necessary but remember that the degree of sedation will depend on the individual patient and drug combination. Warn all patients of the potential effects, and counsel caution with driving or undertaking other skilled tasks.