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BENZODIAZEPINES AND THEOPHYLLINE

Medical Diagnosis and Drugs, Medications
Theophylline and aminophylline may antagonise the effects of the benzodiazepines and zopiclone. Alprazolam levels may also be reduced by theophylline (and therefore probably aminophylline).
The extent to which these xanthines actually reduce the anxiolytic effects of the benzodiazepines remains uncertain but be alert for reduced benzodiazepine effects.
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