BETA BLOCKERS AND FLECAINIDE

The combined use of flecainide and beta blockers may have additive cardiac depressant effects. A study on cardiac function and drug clearance found that when propranolol was given with flecainide the AUCs of both drugs were increased by 20 to 30%, and they had some additive negative inotropic effects. An isolated case of bradycardia and fatal AV block has been reported during the use of flecainide with sotalol, and bradycardia has been reported in a patient taking flecainide and timolol eye drops.
Careful monitoring has been recommended if beta blockers are given with other antiarrhythmics. Monitor for bradycardia.