BETA BLOCKERS AND H2-RECEPTOR ANTAGONISTS
Cimetidine affects the pharmacokinetics of some beta blockers. The AUC of oral labetalol is increased by 66%, metoprolol peak plasma levels are increased by 70%, the AUC of nebivolol is increased by 48%, the AUC of pindolol is increased by about 40%, and the AUC of propranolol is increased by 47%. However, this only rarely appears to result in clinically significant effects.
Monitor the outcome of concurrent use, adjusting the dose of the beta blocker if necessary. Note that other H2-receptor antagonists (e.g. famotidine, nizatidine and ranitidine) do not appear to interact and so may be suitable alternatives.
Monitor the outcome of concurrent use, adjusting the dose of the beta blocker if necessary. Note that other H2-receptor antagonists (e.g. famotidine, nizatidine and ranitidine) do not appear to interact and so may be suitable alternatives.