BETA BLOCKERS AND TRIPTANS
No clinically important interaction occurs between most triptans and propranolol, but the plasma levels of rizatriptan are almost doubled by propranolol.
If propranolol is also given the manufacturers recommend a dosage reduction to 5 mg of rizatriptan, with a maximum of two or three doses in 24 hours. In the UK it is additionally recommended that dosing should be separated by 2-hours, but the basis for this is unclear, as studies have found that this does not modify the interaction.
If propranolol is also given the manufacturers recommend a dosage reduction to 5 mg of rizatriptan, with a maximum of two or three doses in 24 hours. In the UK it is additionally recommended that dosing should be separated by 2-hours, but the basis for this is unclear, as studies have found that this does not modify the interaction.