BOSENTAN AND PHOSPHODIESTERASE TYPE-5 INHIBITORS
Bosentan markedly reduces the AUC of sildenafil (by about 70%) and modestly reduces the AUC of tadalafil (by about 40%). Bosentan levels are modestly reduced by sildenafil and not affected to a clinically relevant extent by tadalafil.
The efficacy of sildenafil and possibly tadalafil may be reduced in patients taking bosentan, whereas the effects of bosentan may be increased in those taking sildenafil (but probably not tadalafil). The outcome of concurrent use should be closely monitored.
The efficacy of sildenafil and possibly tadalafil may be reduced in patients taking bosentan, whereas the effects of bosentan may be increased in those taking sildenafil (but probably not tadalafil). The outcome of concurrent use should be closely monitored.