BUPROPION AND CLOPIDOGREL
Clopidogrel increases the AUC of bupropion by 60% and decreases the AUC of its active metabolite, hydroxybupropion, by about 50%.
Dose adjustments may be needed. It would seem prudent to monitor for increased bupropion adverse effects (lightheadedness, gastrointestinal effects) and efficacy.
Dose adjustments may be needed. It would seem prudent to monitor for increased bupropion adverse effects (lightheadedness, gastrointestinal effects) and efficacy.