BUPROPION AND DEXTROMETHORPHAN
Bupropion may reduce the metabolism of dextromethorphan in some patients.
Dextromethorphan is generally considered to have a wide therapeutic range and its dose is not individually titrated; therefore, the interaction with bupropion is unlikely to be clinically relevant. Nevertheless, it is possible that some patients might become more sensitive to the adverse effects of dextromethorphan while taking bupropion. Note that dextromethorphan is widely found in non-prescrip- tion preparations such as cough suppressants.
Dextromethorphan is generally considered to have a wide therapeutic range and its dose is not individually titrated; therefore, the interaction with bupropion is unlikely to be clinically relevant. Nevertheless, it is possible that some patients might become more sensitive to the adverse effects of dextromethorphan while taking bupropion. Note that dextromethorphan is widely found in non-prescrip- tion preparations such as cough suppressants.