BUPROPION AND PHENYTOIN
Carbamazepine decreases the maximum plasma levels and AUC of bupropion by about 81 to 96%. The AUC of the active metabolite of bupropion is increased by 50%. The manufacturers predict that phenytoin (and therefore possibly fosphenytoin) will interact similarly.
Monitor for any evidence of reduced efficacy (which is likely) and/or increased toxicity (due to the raised metabolite). Note that bupropion is contraindicated in patients with epilepsy.
Monitor for any evidence of reduced efficacy (which is likely) and/or increased toxicity (due to the raised metabolite). Note that bupropion is contraindicated in patients with epilepsy.