BUPROPION AND SSRIS
SSRIs that inhibit CYP2D6 (such as paroxetine and fluoxetine) may raise bupropion levels. Concurrent use has lead to psychosis, mania, seizures, serotonin syndrome and hypersexuality.
The manufacturers of bupropion recommend caution with SSRIs (fluoxetine, paroxetine and sertraline named). Bupropion should be started at the lower end of the dose range in patients taking an SSRI. Note that, a maximum bupropion dose of 150 mg daily is recommended if it is given with other drugs that reduce the seizure threshold.
The manufacturers of bupropion recommend caution with SSRIs (fluoxetine, paroxetine and sertraline named). Bupropion should be started at the lower end of the dose range in patients taking an SSRI. Note that, a maximum bupropion dose of 150 mg daily is recommended if it is given with other drugs that reduce the seizure threshold.