BUPROPION AND TICLOPIDINE
Ticlopidine increases the AUC of bupropion by about 80% and decreases the AUC of its active metabolite, hydroxybupropion, by about 80%.
Dose adjustments may be needed. It would seem prudent to monitor for increased bupropion adverse effects (lightheadedness, gastrointestinal effects) and efficacy.
Dose adjustments may be needed. It would seem prudent to monitor for increased bupropion adverse effects (lightheadedness, gastrointestinal effects) and efficacy.