BUPROPION AND VALPROATE
A study found that the AUC of the active metabolite of bupropion was almost doubled when bupropion was given with valproate. An increase in valproate levels of almost 30% was seen in one patient.
Monitor for any evidence of increased toxicity (due to the raised bupropion metabolites or valproate). Note that bupropion is contraindicated in patients with epilepsy.
Monitor for any evidence of increased toxicity (due to the raised bupropion metabolites or valproate). Note that bupropion is contraindicated in patients with epilepsy.