BUSPIRONE AND CALCIUM-CHANNEL BLOCKERS
Diltiazem and verapamil inhibit CYP3A4, and they can therefore raise the peak levels of buspirone by 3- to 4-fold, which increases the likelihood of adverse effects.
The US manufacturers suggest adjusting the buspirone dose according to response, while the UK manufacturers suggest starting with buspirone 2.5 mg twice daily. Information about other calcium-channel blockers appears to be lacking, but most do not commonly appear to interact by inhibiting CYP3A4.
The US manufacturers suggest adjusting the buspirone dose according to response, while the UK manufacturers suggest starting with buspirone 2.5 mg twice daily. Information about other calcium-channel blockers appears to be lacking, but most do not commonly appear to interact by inhibiting CYP3A4.