BUSPIRONE AND MACROLIDES
In one study the maximum levels and AUC of buspirone were increased 5-fold and 6-fold, respectively, by erythromycin, which resulted in psychomotor impairment and an increase in adverse effects.
Monitor the outcome of concurrent use carefully, expecting to need to reduce the buspirone dosage. The manufacturers suggest a starting dose of buspirone 2.5 mg twice daily. Other macrolides (such as clarithromycin and telithromycin) may also interact, although it seems unlikely that all macrolides will, see macrolides.
Monitor the outcome of concurrent use carefully, expecting to need to reduce the buspirone dosage. The manufacturers suggest a starting dose of buspirone 2.5 mg twice daily. Other macrolides (such as clarithromycin and telithromycin) may also interact, although it seems unlikely that all macrolides will, see macrolides.