BUTENAFINE HYDROCHLORIDE
| BUTENAFINE HYDROCHLORIDE (bu-ten'a-feen) Lotrimin Ultra, Mentax Classifications: antifungal antibiotic; Therapeutic:antifungal antibiotic Prototype: Terbinafine Pregnancy Category: B |
Availability
1% cream
Action
Exerts antifungal action by inhibiting fungal sterol synthesis that is needed in formation of the fungal cell membrane.
Therapeutic Effect
Antifungal effectiveness against interdigital tinea pedis (athlete's foot), tinea corporis (ringworm), and tinea cruris (jock itch).
Uses
Treatment of tinea pedis, tinea corporis, and tinea cruris due to Epidermophyton floccosum, Trichophyton mentagrophytes, Trichophyton rubrum.
Contraindications
Hypersensitivity to butenafine; ophthalmic or vaginal administration.
Cautious Use
Hypersensitivity to naftifine or tolnaftate; pregnancy (category B); lactation. Safety and efficacy in children <12 y are not established.
Route & Dosage
| Tinea Pedis Adult/Child (>12 y): Topical Apply to affected area and surrounding skin b.i.d. times 7 d or q.d. times 4 wk Tinea Corporis, Tinea Cruris Adult/Child (>12 y): Topical Apply to affected area and surrounding skin once daily |
Administration
Topical- Apply sufficient cream to cover affected skin and surrounding areas.
- Do not use occlusive dressing unless specifically directed to do so.
- Store at 5°–30° C (41°–86° F).
Adverse Effects (≥1%)
Skin: Burning/stinging at application site, contact dermatitis, erythema, irritation, itching.Nursing Implications
Assessment & Drug Effects
- Note: 2–4 wk of therapy are usually required for effective treatment.
Patient & Family Education
- Discontinue medication and notify physician if irritation or sensitivity develops.
- Avoid contact with mucous membranes.
- Wash hands thoroughly before and after application of cream.
Common adverse effects in italic, life-threatening effects underlined; generic names in bold; classifications in SMALL CAPS; 
Canadian drug name; 
Prototype drug